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\u3010\u53c2\u8003\u6587\u732e\u3011
1) Blanpain C. Fuchs E: Epidermal homeostasis: a balancing act of stem cells in the skin. Nat Rev. Mol Cell Biol. 10207-217,2009.
2) Matsui T. Amagai M: Dissecting the formation. structure and barrier function of the stratum corneum, Int Immunol, 27 269-280, 2015. 
3) Jones PH. Harper S. Watt FM: Stem cell patterning and fate in human epidermis. Cell. 80 83-93, 1995.
4)Alcolea MP. Jones PH: Lineage analysis of epidermal stem cells, Cold Spring Harb Perspect Med.4 a015206, 2014.
5) Barrandon Y, Green H: Three clonal types of keratinocyte with different capacities for multi- plication, Proc Natl Acad Sci USA. 84:2302- 2306, 1987.
6) Rochat A. Kobayashi K, Barrandon Y: Location of stem cells of human hair follicles by clonal analysis, Cell, 76 1063-1073,1994.
7) Mathor MB, Ferrari G, Dellambra E, et al.: Clonal analysis of stably transduced human epidermal stem cells in culture, Proc Natl Acad Sci USA, 93:10371-10376, 1996.
8) Barrandon Y, Grasset N. Zaffalon A. et al.: Capturing epidermal stemness for regenerative medicine, Semin Cell Dev Biol. 23937-944,2012. 
9) O’Connor NE, Mulliken JB, Banks-Schlegel S. et al. Grafting of burns with cultured epithe- lium prepared from autologous epidermal cells.Lancet, 1:75-78, 1981. gy Vol.33. 2023
10) Gallico GG 3rd. O’Connor NE, Compton CC, et al. Permanent coverage of large burn wounds with autologous cultured human epithelium, N Engl J Med, 311 448-451, 1984.
11) Green H: The birth of therapy with cultured cells, Bioessays, 30 897-903, 2008.
12) Mavilio F. Pellegrini G, Ferrari S, et al. Correc- tion of junctional epidermolysis bullosa by transplantation of genetically modified epidermal stem cells, Nat Med. 12: 1397-1402, 2006.
13) Hirsch T. Rothoeft T. Teig N, et al. Regenera- tion of the entire human epidermis using transgenic stem cells, Nature, 551 327-332, 2017. 
14) Nanba D: Human keratinocyte stem cells: From cell biology to cell therapy. J Dermatol Sci. 96 66-72, 2019.<\/p>\n","protected":false},"excerpt":{"rendered":"\u7d44\u7e54\u7279\u7570\u7684\u5e79\u7d30\u80de\u306b\u3064\u3044\u3066 \u7d44\u7e54\u7279\u7570\u7684\u5e79\u7d30\u80de\u306f\u3001\u500b\u4f53\u306e\u6210\u9577\u3068\u3068\u3082\u306b\u4f5c\u3089\u308c\u3001\u305d\u306e\u5f8c\u306e\u4e00\u751f\u3092\u901a\u3058\u3066\u7d44\u7e54\u306e\u5065\u5eb7\u3092\u7dad\u6301\u3059\u308b\u91cd\u8981\u306a\u7d30\u80de\u3067\u3059\u3002\u76ae\u819a\u3084\u8178\u306a\u3069\u306e\u7d44\u7e54\u3067\u898b\u3089\u308c\u307e\u3059\u3002\u3053\u308c\u3089\u306e\u5e79\u7d30\u80de\u306f\u3001\u53e4\u3044\u7d30\u80de\u306e\u4ee3\u308f\u308a\u306b\u306a\u308b\u65b0\u3057\u3044\u7d30\u80de\u3092\u4f5c\u308b\u3053\u3068 […]","protected":false},"author":8,"featured_media":1081,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"om_disable_all_campaigns":false,"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"categories":[94],"tags":[],"class_list":["post-1276","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-diseases-conditions"],"acf":[],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/xoway2.heteml.net\/pro-clinic\/wp-json\/wp\/v2\/posts\/1276","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/xoway2.heteml.net\/pro-clinic\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/xoway2.heteml.net\/pro-clinic\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/xoway2.heteml.net\/pro-clinic\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/xoway2.heteml.net\/pro-clinic\/wp-json\/wp\/v2\/comments?post=1276"}],"version-history":[{"count":7,"href":"https:\/\/xoway2.heteml.net\/pro-clinic\/wp-json\/wp\/v2\/posts\/1276\/revisions"}],"predecessor-version":[{"id":4390,"href":"https:\/\/xoway2.heteml.net\/pro-clinic\/wp-json\/wp\/v2\/posts\/1276\/revisions\/4390"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/xoway2.heteml.net\/pro-clinic\/wp-json\/wp\/v2\/media\/1081"}],"wp:attachment":[{"href":"https:\/\/xoway2.heteml.net\/pro-clinic\/wp-json\/wp\/v2\/media?parent=1276"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/xoway2.heteml.net\/pro-clinic\/wp-json\/wp\/v2\/categories?post=1276"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/xoway2.heteml.net\/pro-clinic\/wp-json\/wp\/v2\/tags?post=1276"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}